diff --git a/README.md b/README.md index 02cabbe..6a624b6 100644 --- a/README.md +++ b/README.md @@ -26,7 +26,8 @@ Ages 0 to 199: 2428102 infected, 27121 deaths, 1.117% IFR ``` The average IFR for Spain is **1.117%**. However the true IFR may be higher due -to right-censoring and under-reporting of deaths. +to right-censoring, under-reporting of deaths, or low specificity of the serological test; +or the true IFR may be lower due to low sensitivity of the serological test. The Spanish serological study remains the largest published study available to this day. The age-stratified IFR was calculated from three sources: @@ -52,6 +53,24 @@ was only available for 20 585 deaths, and was missing for 6 536 deaths. We assume that these 6 536 deaths were distributed proportionally—not equally—among age brackets, which seems to be a reasonable assumption. +Regarding the specificity of the commercial test used (COVID-19 IgG Rapid Test +Cassette by Zhejiang Orient Gene Biotech Co Ltd) we found various claims, all +100% or close, so no significant false positives are expected: + +* 100% claimed by the manufacturer ([serosurvey][sero], page 3) +* 100% measured by the Ministry of Health ([serosurvey][sero], page 3) +* 99.2% measured by a [third-party][hoffman] + +However the sensitivity is more uncertain: + +* 97% claimed by the manufacturer ([serosurvey][sero], page 3) +* 79% measured by the Ministry of Health ([serosurvey][sero], page 3) +* 93.1% measured by a [third-party][hoffman] + +So a false negative rate anywhere from 3% to 21% could be possible, and we +think it is premature to adjust IFR calculations given the exact sensitivity is +not known. + # Applying the age-stratified IFR to other countries The script `calc_ifr.py` is also able to apply the age-stratified IFR to @@ -75,3 +94,4 @@ health, etc, so this estimate should be interpreted with caution. [daily]: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Actualizacion_120_COVID-19.pdf [dailyalt]: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Actualizacion_109_COVID-19.pdf [wpop]: https://worldpopulationreview.com/countries/spain-population/ +[hoffman]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178815/